Gardy and Loman (2018) is a Nature Reviews Genetics article examining Next Generation Sequencing (NGS) as a step forward towards a genomics-informed, real-time, global pathogen surveillance system. They use the then recent Ebola and Zika outbreaks to demonstrate the need for the continuous surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. The authors present clinical metagenomics and portable sequencing as approaches that contribute toward this vision. They present how genomic epidemiology works with these methods and technologies, examining in particular the 2013-2016 Ebola outbreak in West Africa. The authors propose a model which they call "One Health," which uses portable genome sequencing and digital epidemiology across human, animal and environmental health domains as a basis for a genomics-informed surveillance and outbreak response model. They envision a "sequencing singularity"—the moment at which pathogen, environmental and digital data streams are integrated into a global surveillance system—and presents what would be needed to reach this vision.