Wapl RNAi (Wapl-Cohesin): Kueng et al. (2006)
Kueng et al., Cell (2006)
Wapl Controls the Dynamic Association of Cohesin With Chromatin
https://gyazo.com/2703262497f4bd143459059c89ac83c7
Figure 4
Wapl RNAi showed that unsolved sister chromatids could be observed more frequently.
The length of the chromosomes in Wapl-depleted cells look longer than control cells.
wapl
cohesin
chromosome
chromatin
mitosis
https://gyazo.com/554a31f95e372839b0dfb8f5db542ff3
Figure 5
Scc1, Smc3, and SA1/SA2 antibodies could all stain prophase and prometapahse chromosomes in Wapl-depleted cells.
In Wapl-depleted cells, how do we observe the Hi-C results at mitosis?